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Acetaminophen Beginning of Paper In the late 1800’s it was discovered that papa-amino-phenol, could reduce fever, but the drug was too toxic to use. A less toxic extract called phenacetin was later found to be just as effective but also had pain-relieving properties. In 1949, it was learned that phenacetin was me .... Middle of Paper .... the gastrointestinal tract. It works in about one hour. The liver detoxifies 90% of it by mixing it with sulfuric acid, and another 3-5% is catabolized by enzyme reactions to the acid. The metabolites are excreted in the urine. The dosage of the drug should be used according to the carton instructions. A 10 gram over dose in adults, 140 mg for kids, can cause permanent liver damage. Also if you had just taken some other drugs , The may become more toxic since the drugs are catabolized in the liver. To protect yourself from injury, you s .... 415 words | 2 pages Subscription Length Price Join 30 days membership (recurring) $19.95 90 days membership (recurring) $39.95 180 days membership (non-recurring) $69.95