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Myotonic Dystrophy Beginning of Paper is an dominant disorder characterized by myotonia, muscular dystrophy, cataracts, hypogonadism, frontal balding, and EKG changes. The discovery that the genetic defect is an amplified trinucleotide repeat in the 3-prime untranslated region of a protein kinase gene on chromosome 19 e .... Middle of Paper .... a phenomenon referred to as anticipation. Anticipation occurs more frequently when the gene is passed from mother to child rather than from father to child. Anticipation appears to be explained by the ability of the gene to expand from generation to generation. Amplification is frequently observed after parent-to-child transmission, but extreme amplifications are not transmitted through the male line. This explains anticipation and the occurrence of the severe congenital form almost exclusively in the offspring of affected women. Congenital M .... 598 words | 3 pages Subscription Length Price Join 30 days membership (recurring) $19.95 90 days membership (recurring) $39.95 180 days membership (non-recurring) $69.95